Senators voted 63-37 for Kagan, with Nebraska Democrat Ben Nelson joining most Republicans in opposing Kagan's confirmation.
The total for Kagan's confirmation is one of the lowest levels of support for a Supreme Court nominee in a quarter century.
Five Republicans joined the rest of the Democrats in the Senate in supporting her nomination, including three who normally vote pro-life, Lindsey Graham of South Carolina, Judd Gregg of New Hampshire, and Dick Lugar of Indiana. Two pro-abortion GOP senators, Olympia Snow and Susan Collins of Maine, also voted for Kagan.
Reacting to the confirmation vote in the Senate, pro-life advocates predicted she would become one of the most ardent abortion advocates on the high court.